| Top Individual Performances | |||
| Rank | Player (Date) | Owner | Points |
| 1 | Chad Johnson (Week 10 - 11/14/2006) | Brook | 71 |
| 2 | Lee Evans (Week 11 - 11/21/2006) | John | 71 |
| 3 | Clinton Portis (2003) | Anthony | 70 |
| 4 | Priest Holmes (2002) | Brook | 66 |
| 5 | Kevin Curtis (Week 3 - 9/25/2007) | Chief | 65 |
| Adrian Peterson (Week 9 - 11/6/2007) | Amato | 65 | |
| Michael Vick (Week 10 - 11/14/2010) | Graz | 65 | |
| 8 | Mike Anderson (2000) | Chief | 64 |
| 9 | Jamal Lewis (2003) | Brook | 63 |
| Steven Jackson (Playoffs Sedgwick Bowl - 12/26/2006) | Greg | 63 | |
| 11 | Jimmy Smith (2000) | Jeff | 62 |
| Shaun Alexander (2001) | Greg | 62 | |
| Kenny Britt (Week 7 - 10/24/2010) | John | 62 | |
| 14 | Corey Dillon (2000) | Matthew | 60 |
| Jahvid Best (Week 2 - 9/19/2010) | Graz | 60 | |
| 16 | Michael Vick (2002) | Nando | 59 |
| LaDainian Tomlinson (Week 3 - 9/27/2005) | Brook | 59 | |
| Michael Vick (Playoffs Conference Finals - 12/19/2010) | Graz | 59 | |
| 19 | Priest Holmes (2001) | Brook | 58 |
| Antonio Gates (Week 8 - 11/1/2005) | Chief | 58 | |
| Adrian Peterson (Week 6 - 10/16/2007) | Amato | 58 | |
| 22 | Peyton Manning (2001) | Ascioti | 57 |
| Shaun Alexander (2002) | Greg | 57 | |
| Plaxico Burress (2002) | Chief | 57 | |
| LaDainian Tomlinson (2002) | Brook | 57 | |
| Roddy White (Week 7 - 10/24/2010) | Graz | 57 | |
| 27 | Fred Taylor (2000) | Ascioti | 56 |
| Daunte Culpepper (Week 5 - 10/12/2004) | Jeff | 56 | |
| Terrell Owens (Week 11 - 11/20/2007) | Nando | 56 | |
| 30 | Peyton Manning (Week 8 - 11/21/2004) | Ascioti | 55 |
| Chris Chambers (Week 13 - 12/6/2005) | John | 55 | |
| Reggie Bush (Week 13 - 12/5/2006) | Greg | 55 | |
| Matt Cassel (Week 11 - 11/18/2008) | Nando | 55 | |
| Antonio Bryant (Playoffs 1st Round - 12/9/2008) | Joe | 55 | |
| Terrell Owens (Week 4 - 10/3/2010) | Jeff | 55 | |
| Dwayne Bowe (Week 12 - 11/28/2010) | Matthew | 55 | |
| 37 | Albert Connell (2000) | Matthew | 54 |
| Peyton Manning (2000) | Ascioti | 54 | |
| Marshall Faulk (2002) | Greg | 54 | |
| Atlanta Falcons Defense (2002) | Jeff | 54 | |
| Tiki Barber (Playoffs Conference Finals - 12/20/2005) | Chief | 54 | |
| Chad Johnson (Week 2 - 9/18/2007) | Brook | 54 | |
| Carson Palmer (Week 2 - 9/18/2007) | Laguzza | 54 | |
| Brian Westbrook (Week 3 - 9/25/2007) | Chief | 54 | |
| Arian Foster (Week 1 - 9/12/2010) | Greg | 54 | |
| Darren McFadden (Week 7 - 10/24/2010) | Brook | 54 | |
| Reggie Wayne (Week 13 - 12/5/2010) | Greg | 54 | |
| 48 | NY Jets Defense (2001) | Jeff | 53 |
| Tommy Maddux (2002) | John | 53 | |
| Shannon Sharpe (2002) | Ascioti | 53 | |
| Steve Smith (Week 3 - 9/27/2005) | Steve | 53 | |
| Plaxico Burress (Week 4 - 10/4/2005) | Chief | 53 | |
| Darren McFadden (Playoffs Round 1 - 12/12/2010) | Brook | 53 | |
| 54 | Jeff Garcia (2001) | Brook | 52 |
| Clinton Portis (2002) | Anthony | 52 | |
| LaDainian Tomlinson (2002) | Brook | 52 | |
| Houston Texans Defense (2002) | Free Agent | 52 | |
| Kelly Holcomb (Week 12 - 11/30/2004) | Free Agent | 52 | |
| Donovan McNabb (Week 13 - 12/7/2004) | Anthony | 52 | |
| LaDainian Tomlinson (Week 12 - 11/29/2005) | Brook | 52 | |
| LaDainian Tomlinson (Week 8 - 10/31/2006) | Brook | 52 | |
| Chad Johnson (Week 11 - 11/21/2006) | Brook | 52 | |
| Anquan Boldin (Week 3 - 9/25/2007) | Marc | 52 | |
| Tom Brady (Week 7 - 10/23/2007) | Greg | 52 | |
| Ray Rice (Playoffs Conference Finals - 12/19/2010) | Amato | 52 | |
| Aaron Rodgers (Playoffs Sedgwick Bowl - 12/26/2010) | Jeff | 52 | |
| 67 | Marshall Faulk (2000) | Kirsch | 51 |
| Edgerrin James (2000) | Kirsch | 51 | |
| Daunte Culpepper (2002) | Jeff | 51 | |
| Trent Green (2002) | Marc | 51 | |
| Billy Volek (Playoffs Conference Finals - 12/21/2004) | Chief | 51 | |
| Santana Moss (Playoffs Sedgwick Bowl - 12/27/2005) | Anthony | 51 | |
| Torry Holt (Week 6 - 10/17/2006) | Jeff | 51 | |
| Hines Ward (Week 7 - 10/24/2006) | Ilacqua | 51 | |
| Baltimore Ravens Defense (Week 12 - 11/28/2006) | Brook | 51 | |
| Steve Smith (Week 2 - 9/18/2007) | Steve | 51 | |
| LaDainian Tomlinson (Week 6 - 10/16/2007) | Brook | 51 | |
| Terrell Owens (Week 12 - 11/25/2008) | Nando | 51 | |
| Dwayne Bowe (Week 10 - 11/14/2010) | Matthew | 51 | |
| 80 | Peyton Manning (2003) | Ascioti | 50 |
| Javon Walker (Week 3 - 9/28/2004) | Matthew | 50 | |
| Larry Johnson (Week 8 - 10/31/2006) | Chief | 50 | |
| Javon Walker (Week 9 - 11/7/2006) | Matthew | 50 | |
| Joseph Addai (Week 12 - 11/28/2006) | John | 50 | |
| Roy Williams (Week 3 - 9/25/2007) | Ascioti | 50 | |
| Jason Witten (Playoffs Round 1 - 12/11/2007) | Jeff | 50 | |
| Michael Turner (Week 1 - 9/9/2008) | Ilacqua | 50 | |
| Dallas Clark (Playoffs Conference Finals - 12/16/2008) | Greg | 50 | |
| Matt Forte (Week 1 - 9/12/2010) | Jeff | 50 | |
| Antonio Gates (Week 4 - 10/3/2010) | Chief | 50 |